Work

Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx

Year: 2026

Type: article

Abstract: in which induced mesenchymal stem cell-derived exosomes were shown to exhibit a stronger and more sustained anti-proliferative effect by inducing a senescence-like state without apoptosis. The results obtained by the authors highlight the features of the effects of senescent drift induction in surrounding tissues. In the light of these findings, the role of the properties of extracellular matrix and cellular glycocalyx in responses of human tumors to therapy remain uninvestigated. These extracellular barriers appear to be significant obstacles to effective cancer therapy, especially in relation to the use of unique properties of tumor microenvironment for the immunotherapy-resistant cancer treatment.

Source: World Journal of Stem Cells

DOI: 10.4252/wjsc.v18.i1.115655

Authors: Ilya D Klabukov, Anastas Kisel, Elena Yatsenko, Yana Sulina, Denis S Baranovskii

Institutions: Medical Radiological Research Center, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Sechenov University, InSysBio (Russia)

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7124905295