Work

Changes in body composition and resting energy expenditure during the first year after Roux-en-Y or one-anastomosis gastric bypass

Year: 2026

Type: article

Abstract: Resting energy expenditure declines after bariatric surgery, but the relative roles of tissue loss and adaptive thermogenesis are unclear. Using DXA-based organ-tissue estimates with indirect calorimetry, we show that adaptive thermogenesis accounted for ∼44% of the 6-mo postoperative REE decline, with the remainder due to tissue loss. Adaptive thermogenesis was not robustly detectable at 12 mo. Roux-en-Y and one-anastomosis gastric bypass show similar body composition and REE changes.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00185.2025

Authors: Jari E. Karppinen, Sini Heinonen, Tuure Saarinen, Birgitta W. van der Kolk, Ulla Säiläkivi, Henna Sammalkorpi, Anne K. Penttilä, Per-Henrik Groop, Anne Juuti, Kirsi H. Pietiläinen

Institutions: University of Helsinki, Helsinki University Hospital, Baker Heart and Diabetes Institute, Folkhälsans Forskningscentrum, Monash University

Language: English

Topic: Bariatric Surgery and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Suomen Lääketieteen Säätiö, European Foundation for the Study of Diabetes, Academy of Finland, Signe ja Ane Gyllenbergin Säätiö, Sigrid Juséliuksen Säätiö, Orionin Tutkimussäätiö, Paulon Säätiö, Diabetesliitto, Paavo Nurmen Säätiö, Novo Nordisk Fonden

Awards: G1224646995, Novel targets to activate adipose tissue metabolism for the treatment of obesity, ADIPOSE AND MUSCLE TISSUE MITOCHONDRIAL PROFILING AS A KEY TO RENEWING THE TREATMENT OF OBESITY, G2211207374, G4043554698, G4137419029, G4411580604, G484840104, G5057296940, G5585251843, Individualized treatments for obesity based on mitochondrial biology, G6644446059, G7098505423, G837227766, G8830438197, G96990336

OpenAlex ID: W7124914621

FWCI: 6.357

Cites: 43

Cited by: 1

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