Work

5,5′-Methylenedisalicylic Acid Derivatives as Inhibitors of the Protein Phosphatase CppA in Chlamydia trachomatis

Year: 2026

Type: article

Abstract: A structure-based designed library of new 5,5’-methylenedisalicyclic acid (MDSA) derivatives were synthesized as a func-tional core and explored for their anti-bacterial activity against Chlamydia trachomatis. Various well-established reactions such as amide coupling, basic ester hydrolysis, phosphorylation, sulfonation, acetylation, and hydrogenation reactions were utilized to tune or substitute the carboxylic acid and phenolic groups of MDSA, converting them into amide, ester, phos-phoryl, sulfonyl and acetyl functionalities. Both symmetrical and asymmetrical derivatives were prepared and subsequently tested for mammalian cell cytotoxicity, CppA enzyme inhibition, and inhibition of infection.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00537

Authors: Krishna Pandey, Olivia Slater, Gabrielle E. Jeschke, Maria Kontoyianni, Kyle N. Plunkett, Derek J. Fisher

Institutions: Southern Illinois University Carbondale, Southern Illinois University Edwardsville

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Health Sciences, National Institute of Allergy and Infectious Diseases