Work

Diacylglycerol O-acyltransferase 2 (DGAT2): a novel therapeutic target for Alzheimer’s disease through modulation of microglial lipid synthesis

Year: 2026

Type: article

Abstract: Recently, a study published in the Immunity has elucidated the mechanism by which amyloid-β (Aβ) induces lipid droplet accumulation in microglia in Alzheimer's disease[1]. The study identified diacylglycerol O-acyltransferase 2 (DGAT2) as a key enzyme playing a critical role in this process.

Source: Medicine Plus

DOI: 10.1016/j.medp.2026.100118

Authors: Yu Chen, Jing Tian

Institution: Shenzhen University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Shenzhen-Hong Kong Institute of Brain Science, Basic and Applied Basic Research Foundation of Guangdong Province