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High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain

Year: 2026

Type: article

Source: ACS Nano

DOI: 10.1021/acsnano.5c19138

Authors: Emily L. Han, Dongyoon Kim, Amanda M. Murray, Kaitlin Mrksich, Alex G. Hamilton, Sophia Tang, Soyeon Yoo, Audrey T. Zhu, Elaine R. Tong, Rohan Palanki, Michelle L. Hall, Sean K. Bedingfield, Michael J. Mitchell

Institutions: University of Pennsylvania, Eli Lilly (United States), Abramson Cancer Center

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Science Foundation, Burroughs Wellcome Fund, Eli Lilly and Company

Award: Graduate Research Fellowship Program(GRFP)

OpenAlex ID: W7124948137

FWCI: 7.311

Cites: 52

Cited by: 4

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