Year: 2026
Type: article
Abstract: Chiral sodium sulfinates serve as crucial synthetic intermediates utilized for rapidly producing a variety of enantioenriched sulfone derivatives that are pervasive in the fields of pharmaceutical chemistry and chemical synthesis. Here we present a practical and highly effective method for the nickel-catalyzed asymmetric sulfonation of propargylic carbonates for the production of essential synthetic building blocks. Notably, sodium 1-methyl 3-sulfinopropanoate (SMOPS), a commercially available sulfonylation reagent, has potential for in situ unmasking and functionalization in the formation of enantioenriched sulfinate salts for diverse product diversification. With operational simplicity and remarkable tolerance toward diverse functional groups, this methodology provides an extensive collection of biologically relevant propargylated, allenylated, and 1,3-dienylated sulfones, with excellent yields and regio- and stereoselectivities. Chiral sodium sulfinates serve as crucial synthetic intermediates utilized for rapidly producing a variety of enantioenriched sulfone derivatives that are pervasive in the fields of pharmaceutical chemistry and chemical synthesis. Here, the authors report the nickel-catalyzed asymmetric sulfonation of propargylic carbonates, synthesizing chiral sulfinates, propargylated, allenylated, and 1,3-dienylated sulfones with high enantioselectivity.
Source: Nature Communications
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,990
Award: 新型手性膦催化的不对称自由基反应研究
OpenAlex ID: W7124952049