Work

Prenatal Exposure to Wildfire and Autism in Children

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Chronic health effects of wildfire PM 2.5 on neurodevelopmental outcomes are largely unknown. Therefore, the effects of wildfire PM 2.5 on autism were assessed in a southern California-based pregnancy cohort using Cox proportional hazard models. Exposure was estimated from 2006 to 2014 at maternal addresses across pregnancy and individual trimesters using three metrics: (1) mean wildfire PM 2.5 concentration, (2) number of days of smoke exposure, and (3) number of waves of smoke exposure. Analysis was restricted to days over specific PM 2.5 concentration thresholds (3 and 5 μg/m 3 ). Nonmovers during pregnancy (75% of cohort) were assessed in sensitivity analyses. There were 3356 autism diagnoses by age 5. Autism risk was associated with increased number of wildfire-exposed days during the third trimester and was strongest for nonmovers. Nonmover hazard ratios (HR) with exposure to 1–5, 6–10, and >10 wildfire days in the third trimester (compared to none) were 1.108 (95% CI: 1.010,1.215), 1.118 (0.957,1.307), and 1.225 (1.043,1.440), respectively. HR per wildfire wave increase (>3 μg/m 3 for 2 consecutive days) during the third trimester were 1.073 (1.009,1.140) and 1.267 (1.054,1.205) for the entire cohort and nonmovers, respectively. There was no association with the mean wildfire PM 2.5 concentration alone. Prenatal exposure to wildfire smoke may increase risk of autism among children.

Source: Environmental Science & Technology

DOI: 10.1021/acs.est.5c08256