Work

Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Year: 2026

Type: article

Abstract: DICER1-mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of DICER1-mutated thyroid nodules. In this case report, we presented a DICER1-mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a DICER1-mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.

Source: Cytopathology

DOI: 10.1111/cyt.70053

Authors: Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, Qian Wang