Work

Boosting the Speed and Accuracy of Protein Quantification Algorithms in Mass Spectrometry-Based Proteomics

Year: 2026

Type: article

Abstract: Current methods for protein level quantification in mass spectrometry-based proteomics do not scale with the increasing number of samples because of limited system memory and algorithmic complexities. Here we propose a new data structure that supports parsing of input as data stream, improve state of the art quantitation methods in performance by orders of magnitudes, and provide a generic method to boost the precision and accuracy by fragment weighting.

Source: Journal of Proteome Research

DOI: 10.1021/acs.jproteome.5c01038