Work

Microwave reactor assisted chiral Brønsted acid catalyzed asymmetric synthesis

Year: 2026

Type: article

Abstract: Microwave reactors have been used in organic synthesis to facilitate reactions since the 1980s. In this paper we show that the reaction time can be substantially shortened for our previously developed chiral Brønsted acid catalyzed desymmetrization of diesters to yield lactones when performed in the microwave from 72 h to 20 min without loss in yield or enantiopurity. Three additional organocatalyzed asymmetric reactions from current literature were explored and shown to exhibit similar benefits with the use of a microwave reactor. Although not traditionally thought of as a tool in asymmetric organocatalysis, we show that microwave reactors can benefit many enantioselective reactions, particularly those with long reaction times. • Microwave reactor decreases reaction time without loss of yield or enantiopurity. • Four examples using chiral Brønsted acids given. • Procedures easily adapted.

Source: Tetrahedron Letters

DOI: 10.1016/j.tetlet.2026.155976

Authors: Jesscia E. Carsley, Mason T. Gates, Kimberly S. Petersen

Institution: University of North Carolina at Greensboro

Language: English

Topic: Microwave-Assisted Synthesis and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

Funders: Foundation for the National Institutes of Health, National Institutes of Health, University of North Carolina at Greensboro, National Institute of General Medical Sciences