Work

Maternal Obesity and MicroRNAs in Breast Milk: Implications for Infant Developmental Programming

Year: 2026

Type: article

Abstract: This review explores the relationship between maternal obesity and alterations in the expression of microRNAs (miRNAs) in breast milk, highlighting how these changes may influence the developmental programming of the infant. Evidence suggests that maternal obesity can affect the bioactive composition of breast milk, including miRNA profiles, which are key regulators of metabolic and immune pathways in early life. Specific miRNAs, such as miR-148a and miR-30b, have been identified as modulators of metabolic processes, potentially impacting offspring growth, energy balance, and long-term health outcomes. Additionally, maternal factors such as prepregnancy BMI and dietary patterns play a crucial role in shaping milk composition. Understanding these complex interactions is essential for informing nutritional strategies aimed at supporting optimal infant development and preventing chronic diseases later in life.

Source: Obesity Reviews

DOI: 10.1111/obr.70098

Authors: Gyslane M. Santos, Fabíola Isabel Suano de Souza, Luciana P. Pisani

Institution: Universidade Federal de São Paulo

Language: English

Topic: Infant Nutrition and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Estimated APC paid: $5,450