Work

Genome-wide analysis of long non-coding RNAs and mRNAs in lung adenocarcinoma with pulmonary thromboembolism

Year: 2026

Type: article

Abstract: Introduction: Pulmonary thromboembolism (PTE) is a serious complication in patients with lung adenocarcinoma (LUAD), yet its molecular mechanisms remain poorly understood. This study aimed to investigate the expression profiles of long non-coding RNAs (lncRNAs) and mRNAs in LUAD patients complicated by PTE. Methods: Peripheral blood samples were collected from LUAD patients with PTE and from three control groups (LUAD-only, PTE-only, and healthy controls). RNA sequencing was performed to identify differentially expressed lncRNAs and mRNAs among groups. Results: RNA sequencing revealed significant dysregulation of transcripts. Compared with LUAD-only patients, 725 lncRNAs and 2,052 mRNAs were differentially expressed in the LUAD + PTE group. Compared with PTE-only patients, 932 lncRNAs and 2,206 mRNAs were differentially expressed, while comparison with healthy controls identified 1,190 lncRNAs and 3,001 mRNAs. Key dysregulated transcripts included MERGE.31027.6, ENST00000318988, MERGE.30976.2, and ENST00000397519. Enrichment analyses highlighted immune response-related pathways, cytokine signaling, and the NF-κB signaling pathway. Conclusion: These findings suggest that aberrant lncRNA and mRNA expression may contribute to the pathogenesis of LUAD complicated by PTE and may serve as potential biomarkers and therapeutic targets for prognosis and treatment.

Source: Frontiers in Genetics

DOI: 10.3389/fgene.2025.1683576

Authors: Maryamgvl Ahmat, Gvzalnur Alim, Zhu Zhu, Chao Chen, Guolei Cao, Qin Luo

Institution: Xinjiang Medical University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801