Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection
Year: 2025
Type: article
Study design: Case Report
Abstract: We report an adolescent with perinatal HIV-1 infection treated from 1 month of age. Despite persistent viremia until age 4, he exhibited negative or weakly reactive serologies and no detectable intact proviruses at 11 and 18 years. This case questions current definitions of seroconversion, HIV persistence and remission in children.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofaf815
Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Institut Cochin, Institut Pasteur, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Hôpital Necker-Enfants Malades, Laboratoire d'hématologie, Université d'Orléans, Centre hospitalier universitaire d'Orléans, Laboratoire Interdisciplinaire pour l’Innovation et la Recherche en Santé d’Orléans, Fédération pour la recherche en explorations thérapeutiques innovantes in utero
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W7125113244