Work

Modeling immunotherapies in live 3D human cancer tissue bioreactors

Year: 2026

Type: article

Abstract: This optimized bioreactor culture system provides a robust platform for evaluating immunotherapy efficacy within a physiologically relevant TME. It offers valuable potential for advancing personalized treatment strategies, accelerating the understanding of immunotherapy mechanisms, and improving clinical outcomes.

Source: Theranostics

DOI: 10.7150/thno.118298

Authors: Yizheng Zhang, Ivan Foth, Ahmad Makky, Philip Bucher, Melanie Grimm, Peter-Martin Bruch, Ilona Hagelstein, Sascha Dietrich, Josef Leibold, Lukas Flatz, Judith Feucht, Sven Becker, Christian M. Schürch

Institutions: Universitätsklinikum Tübingen, University of Tübingen, University Children's Hospital Tübingen, Heidelberg University, Düsseldorf University Hospital, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W7125129170

FWCI: 1.73

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Cited by: 1

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