Regio Selective Arylation and Synthesis of New Alkyl−/Aryl−/Hetero‐3,6‐di‐Bromo‐5‐(Pyridine‐4‐yl)‐1,4‐Diazine‐2‐Carboxamidate Derivatives
Year: 2026
Type: article
Abstract: ABSTRACT The heterocyclic scaffold natural products are abundant and widely scattered in nature, playing a vital role in human life, stirring up broad importance from scientists as they are accomplished of providing valuable properties. Among these, 6‐membered 1,4‐diazipene‐2‐carbaxamides have attracted considerable attention owing to their interesting and potent biological properties. In this article, we report the synthesis of several Pyrido‐pyrazine‐2‐carboxamide ( 5a‐l ) analogs with an efficient procedure in good to excellent yields and with high regio‐selectivity by chemical transformations. This is the first report on the preparation of pyridine‐containing tetra‐substituted pyrazine‐2‐carbaxamide skeletons synthetic route to get novel 3,6‐dibromo‐5‐(pyridine‐4‐yl)‐1,4‐diazine‐2‐carbaxamide ( 5a‐l ) scaffolds to establish the current state of the art in this area.
DOI: 10.1002/jhet.70165
Institutions: Osmania University, National Institute of Technology Warangal
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Osmania University
OpenAlex ID: W7125144178