Work

Butyrate ameliorates doxorubicin-induced heart failure by inhibiting cardiomyocyte ferroptosis through the gut-heart axis

Year: 2026

Type: article

Abstract: levels, and inhibited cardiomyocyte ferroptosis. Further results confirmed that NaB mitigated DOX-induced ferroptosis via the GPX4/GSH pathway. Collectively, this study indicated that butyrate ameliorates DIHF by inhibiting cardiomyocyte ferroptosis through the gut-heart axis, providing translational potential for microbiota-targeted cardioprotective strategies in DIHF.

Source: iScience

DOI: 10.1016/j.isci.2026.114754

Authors: Shibin Zeng, Qing Xie, Rong Zhang, Ting Yang, Dan Liu, Jiani Zhang, Shudong Ma, Xiaozhong Qiu

Institutions: Nanfang Hospital, Southern Medical University, The First People's Hospital of Shunde, Fuda Cancer Hospital

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Guangzhou Science and Technology Program key projects, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1718662700, G4010679305, G4022356458, G5787805600, G6916070756, G8517229131, G8696126393

OpenAlex ID: W7125165398

FWCI: 22.76

Cites: 48

Cited by: 5

Related to: