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Overcoming Ceftaroline Resistance in MRSA Using Ceftaroline–Carbapenem Combination Therapy

Year: 2025

Type: article

Abstract: The limited but rising threat of ceftaroline-resistant MRSA poses a therapeutic challenge. We show that ceftaroline plus carbapenems restores activity against a resistant strain both in vitro and in a murine bacteremia model. These findings support combination therapy as a potential strategy for difficult MRSA infections, warranting further clinical investigation.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofag009

Authors: Joshua Olson, Valliammai Alaguvel, Gabriel Pérez-Parra, Allen Jankeel, Anuj K Khetarpal, Valeria Rodríguez-Guevara, Vanessa Vu, George Sakoulas, Erlinda R Ulloa

Institutions: University of California, Irvine, Brown University, University of California San Diego, Sharp Rees-Stealy Medical Group, Children's Hospital of Orange County

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053

Funders: Norges Idrettshøgskole, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G127884959, G900977719

OpenAlex ID: W7125184265

FWCI: 0.709

Cites: 19

Cited by: 1

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