Figure 1 from Transcriptomic Analyses of Normal Human Pancreata Reveal the Presence of Cancer Subtypes that Correlate with Acinar Ductal Metaplasia and Donor Ancestry
Year: 2026
Type: other
Abstract: Normal pancreatic acinar cells display molecular subtypes. Sixty-nine specimens of primary, normal pancreas underwent bulk transcriptomic sequencing. A, The gene expression data were subjected to spectral clustering analysis, and the resulting data were plotted using PCA. The analysis showed the separation of two different subtypes of donors referred to as group 1 and group 2. B, Supervised hierarchical clustering of group 1 and group 2 samples using the basal (Moffitt), classical (Moffitt), and exocrine (Collisson) subtype genes sets. Mean expression of the exocrine (C), classical (D), and basal (E) subtypes as stratified by group. GSEA was performed on the bulk RNA transcriptomic data from the uncultured, normal human pancreatic acinar cells from 69 donors. Shown are the data from the group 1 and group 2 subtypes using the (F) exocrine, (G) basal, (H) Gruetzmann PDAC down and (I) Gruetzmann PDAC up, and (J) KRAS down and (K) KRAS up gene sets. GSEA for (K) ADMIUp and ADMIDown gene sets in the group 1 and group 2 classified samples. Mean ± SD. Two-tailed Mann–Whitney U test. CPM, counts per million; ES, enrichment score; PC, principal component.
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7125193233
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