Work

Transhepatic Access for Left Atrial Appendage Closure in a Patient With Inferior Vena Cava Interruption

Year: 2026

Type: article

Abstract: BACKGROUND: Left atrial appendage occlusion (LAAO) is an alternative stroke-prevention strategy in patients with nonvalvular atrial fibrillation who have contraindications to oral anticoagulation. Femoral venous access is the standard approach. CASE SUMMARY: We report a 78-year-old woman with nonvalvular atrial fibrillation, high bleeding risk due to recurrent falls, and prior traumatic subdural hematoma, referred for LAAO. The initial procedure attempt was aborted after intraprocedural discovery of congenital inferior vena cava interruption, precluding femoral access. In a second stage, the procedure was successfully completed via transhepatic venous access without complications. DISCUSSION: This case highlights the feasibility of transhepatic access for structural heart interventions in patients with complex venous anatomy. TAKE-HOME MESSAGES: Transhepatic access is a safe alternative for LAAO in patients with inferior vena cava interruption. Preprocedural imaging and flexible access strategies are essential in structural interventions for patients with complex venous anatomy.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.106614