Effect of Baicalein on Odontogenic Differentiation of Dental Pulp Stem Cells: An In Vitro Study
Year: 2026
Type: article
Abstract: examples of scaffolds, which serve as physical matrices to promote cell migration and organization.Cellular differentiation and tissue repair are guided by signaling molecules, including growth factors that are generated during root canal disinfection or obtained from platelet concentrates.7,8 The endodontic treatment of injured immature teeth might undergo a paradigm change thanks to this trifecta, which replaces conventional obturation methods with physiologically based, regenerative results. IntroductIonTraumatic dental injuries (TDIs) are widespread around the world and continue to be a significant contributor to dental morbidity in people of all ages.According to epidemiological data, up to 30% of children and 25% of adults will suffer from dental trauma at some point in their lives.1,2 Complex endodontic intervention is frequently required for the treatment of TDIs, particularly in cases where pulp necrosis develops.Conventional root canal therapy is usually necessary for mature teeth.However, regenerative endodontic operations (REPs), particularly revascularization, have virtually replaced traditional apexification in young permanent teeth with inadequate root growth.By utilizing the apical blood supply and remaining stem cells, revascularization makes use of the body's healing capacity to restore pulp vitality and promote further root formation.3,4 According to clinical data, this biologically based strategy encourages periapical pathosis resolution as well as dentinal wall thickening and apical closure, both of which are essential for longterm tooth preservation.5,6 The idea of the tissue engineering triad-which consists of stem cells, scaffolds, and growth factors-is essential to regenerative endodontic treatments.Together, these elements form a microenvironment that promotes pulp-dentin regeneration.The regeneration capacity is supplied by stem cells, such as those found in dental pulp stem cells (DPSCs) and the stem cell apical papilla (SCAP).Autologous blood clots and biomimetic materials are 1,2,
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7125246644