Year: 2026
Type: article
Abstract: Background: Ovarian cancer remains lethal and shows limited response to immunotherapy partly due to immune evasion. We mapped global research trends on ovarian cancer immune evasion during 2015-2024. Methods: Web of Science Core Collection and Scopus were searched on 6 Oct 2025 for English articles and reviews published 1 Jan 2015-31 Dec 2024. Records were merged and deduplicated in R (bibliometrix). Productivity, collaboration, keywords, thematic clusters, and burst terms and citations were analyzed using bibliometrix, VOSviewer, and CiteSpace. Results: A total of 496 publications from 202 sources were included, showing rapid growth (annual growth rate ~24.6%) with a marked rise after 2020. The United States and China contributed the most output, whereas international collaboration was limited (~9.7% of authors with multiple-country affiliations). Keyword co-occurrence revealed major themes in immunotherapy, tumor microenvironment remodeling, immune checkpoint regulation, resistance mechanisms, and genetic/epigenetic modulation. Emerging hotspots highlighted tumor-associated macrophages and STAT3-centered signaling as key drivers of immune suppression and therapeutic resistance. Conclusion: Research on ovarian cancer immune evasion is expanding quickly and is shifting toward actionable targets and combination strategies. Strengthening cross-country collaboration and focusing on TME- and STAT3/TAM-directed interventions may accelerate translation and improve immunotherapy outcomes.
Source: Frontiers in Oncology
Institution: Central South University
Language: English
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G7515642992
OpenAlex ID: W7125260240