Year: 2026
Type: article
Study design: Observational Study
Abstract: Background Vitamin D insufficiency is a global public health concern, particularly among Chinese pregnant women, yet southwest-China data using gold-standard LC-MS/MS are scarce. Methods A retrospective cohort study was conducted on 2,742 pregnancies delivered in Deyang. Serum 25(OH)D2 and 25(OH)D3 quantified by LC-MS/MS (CV < 7%). Univariate and multivariate logistic regression analyses were used to identify risk factors for vitamin D deficiency and assess its associations with pregnancy outcomes. Efficacy of vitamin D supplementation was also compared. Results The median serum 25(OH)D concentration was 16.3 ng/ml, with 62.5% of participants classified as vitamin D deficient (<20 ng/ml). Early pregnancy (≤12 weeks) carried 3.37-fold higher deficiency risk than late pregnancy (≥25 weeks). Early deficiency was associated with gestational hypothyroidism (OR = 1.32, P = 0.048). Paradoxically, late deficiency inversely correlated with preterm birth (OR = 0.32, P = 0.014). One-month supplementation: D3-800 IU raised 25(OH)D by +28.4 ng/ml, outperforming D2-800 IU (+14.6 ng/ml, P < 0.001). Conclusions Vitamin D deficiency affects three-fifths of gravidae in Deyang. Early pregnancy represents the highest-risk window and predicts hypothyroidism. Late deficiency unexpectedly linked to lower preterm birth warrants causal clarification. D3 is the preferred supplement.
Source: Frontiers in Medicine
Authors: Mao Zheng, Yali Wang, Ning Zou, Jianfei E., Yu Zou
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G8893836208
OpenAlex ID: W7125364139