Synthesis of Tetrahydroisoquinolinoquinolines via Sequential Pd-Catalyzed N-Arylation and Pd-Catalyzed Alkene Carboamination Reactions
Year: 2026
Type: article
Abstract: The synthesis of substituted tetrahydroisoquinolinoquinolines via a two-step route involving a Pd-catalyzed N-arylation reaction followed by a Pd-catalyzed alkene carboamination reaction is described. The combined transformations lead to the generation of two rings and three bonds (two C–N and one C–C) and the heterocyclic products are obtained in moderate to good yields.
Source: Synthesis
DOI: 10.1055/a-2759-6397
Authors: Kathryn G. Berges, Gabriel A. Gonzalez, Glorimar Miranda-Mendez, John P. Wolfe
Institution: University of Michigan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7125374107