Work

Role of interstitial cells of Cajal in regulating tone and responses to enteric motor neurons in the murine pyloric sphincter

Year: 2026

Type: article

Abstract: The pyloric sphincter is an electrical insulator between the stomach and small intestine, isolating and maintaining the unique motility patterns of these organs. Using Ca 2+ imaging techniques, this study demonstrates why slow waves do not propagate between organs and how interstitial cells of Cajal serve to regulate pyloric tone and responses to enteric motor neurons.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00350.2025

Authors: Ji Yeon Lee, Sang Don Koh, Sal A. Baker, Kenton M. Sanders

Institution: University of Nevada, Reno

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, Division of Diabetes, Endocrinology, and Metabolic Diseases