Work

The value of proportion of perfused vessels change rate in the evaluation of early organ function deterioration in septic shock and ARDS

Year: 2026

Type: article

Abstract: Background Severe organ function deterioration is associated with poor prognosis in patients with septic shock combined with ARDS. This study aimed to develop a validated predictive model for early organ function deterioration and to evaluate the factors associated with this deterioration, as well as the prognosis, in patients with septic shock combined with ARDS. Methods This is a retrospective study including 67 patients with septic shock combined with ARDS. Patients were categorized into two groups based on the change in their Sequential Organ Failure Assessment (SOFA) score over 24 h: the organ function deterioration group (SOFA 24h − 0h score ≥ 1) and the non-deterioration group (SOFA 24h − 0h score <1). The sublingual microvasculature of patients was assessed using microcirculatory microimaging to obtain metrics such as proportion of perfusion vessel change rate (ΔPPV), which were then analyzed to characterize the patients with early organ function deterioration. Results There were a total of 34 patients with early organ function deterioration. ΔPPV and LCR were independently associated with early organ function deterioration, and ΔPPV and lactate clearance rate (LCR) were associated with ΔSOFA. The AUC for ΔPPV was 0.813 (95% CI: 0.707–0.919), and when combined with the LCR, the AUC was 0.871 (95% CI: 0.785–0.957). Conclusions Deterioration of organ function is common in patients with septic shock combined with ARDS and early detection is crucial. Microcirculation is an important factor in safeguarding organ function. We developed a predictive model to predict the risk of early organ function deterioration, and the combination of ΔPPV and LCR may merit further investigation.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1733855

Authors: Shuya Huang, Xiaoyan Li, Rui Dong, Yanqiu Gao

Institutions: Zhengzhou University, Zhengzhou Central Hospital

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801