Year: 2026
Type: article
Abstract: defective receptor editing and persistence of autoreactive immature B cells may be an important mechanism in the pathogenesis of other autoimmune diseases.8 The findings by Sheng et al support a breakdown in early B-cell central tolerance due to deficient BCR editing is a key contributor to pathophysiology of ITP.Characterization of the mechanisms underlying the repression of RAG and ineffective BCR editing in immature B cells will be critical to identify new opportunities for diagnosis, risk stratification, and treatment of patients with ITP.
Source: Blood
Authors: Kenneth Shain, Rachid Baz
Institution: Moffitt Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7125390786