Work

Synthesis, Structural Characterization, and In Silico Evaluation of the Salicylidene Schiff Base 4-{( E )-[(2,3-Dihydroxyphenyl)methylidene]amino}-2-hydroxybenzoic Acid as a Promising Scaffold for Human Transthyretin Inhibitor

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The Schiff base derived from the condensation of 4-aminosalicylic acid with 2,3-dihydroxybenzaldehyde was synthesized and characterized by using experimental techniques, theoretical calculations, and in silico methods. Single-crystal X-ray diffraction analysis showed that the compound crystallizes in the triclinic P 1̅ space group with two molecules in the asymmetric unit, both adopting a zwitterionic keto form. In silico studies predict high gastrointestinal absorption, low toxicity, and potential activity as a transthyretin (TTR) inhibitor, with binding affinity comparable to that of the drug Tolcapone, suggesting that the synthesized compound may be a promising scaffold for a TTR stabilizer.

Source: ACS Omega

DOI: 10.1021/acsomega.5c07247

Authors: Patryk Nowak, Artur Sikorski

Institution: University of Gdańsk

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935