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Non-steroidal anti-inflammatory drugs (NSAID)-induced allergic myocardial infarction (Kounis syndrome)

Year: 2026

Type: article

Abstract: Anaphylactic acute coronary syndrome (Kounis syndrome) is under-recognized due to its wide spectrum of manifestations, ranging from asymptomatic cardiac biomarker elevation to frank ST-segment elevation myocardial infarction (STEMI). We report a middle-aged female who developed acute onset chest pain with diffuse maculopapular rash after an injection of diclofenac. In the setting of anaphylaxis, she had elevated tryptase and was diagnosed with allergic non-STEMI (NSTEMI). She was managed with epinephrine, steroids, and antihistamines. Prompt recognition of this clinical entity is vital for its successful treatment.

Source: The National Medical Journal of India

DOI: 10.25259/nmji_523_2024

Authors: NAVEENKUMAR NALLATHAMBI, MANIEVELRAAMAN KANNAN, ANBARASAN SEKAR

Institution: Madras Medical College

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7125408358