Work

Design and validation of Offset Split-P porous titanium implants for mandibular defect repair

Year: 2026

Type: article

Abstract: In recent years, the incidence of mandibular defects caused by tumors, traffic accidents, and international conflicts has been steadily increasing, while the availability of autograft and allograft resources remains severely limited. Therefore, designing mandibular implants with matched mechanical properties and favorable biocompatibility is of great significance. In this study, a mandibular implant based on an offset-optimized and gradient-designed "Offset Splitp" structure was developed and fabricated. The feasibility of the porous implant was systematically assessed through mechanical simulations, fluid dynamic analyses, compression testing, in vitro cell culture, and corrosion immersion experiments, employing small-scale Ti-6Al-4V offset Splitp structures (unit cell: 5 × 5 × 5 mm; strut diameter: 0.5 mm). The results demonstrate that this structure exhibits superior mass transport performance compared with four common topologies (Gyroid, Schwarz, Diamond, and Neovius). At porosities consistent with the human mandible (60%–90%), its elastic modulus (3.83–18.89 GPa) and yield strength (28.51–171.90 MPa) both meet the requirements for bone implants, while maintaining excellent biocompatibility. Moreover, it promotes cell proliferation, directional migration, and osteogenic differentiation, and shows outstanding corrosion resistance, ensureing long-term structural stability.

Source: Materials & Design

DOI: 10.1016/j.matdes.2026.115533