Clonal Profiles in a Li–Fraumeni Syndrome Patient With SHH Medulloblastoma: Clonal Evolution, Genomics, and Clinical Implications
Year: 2026
Type: article
Study design: Case Report
Abstract: The authors declare no conflicts of interest. Figure S2 Pedigree with autosomal dominant inheritance of early-onset cancers consistent with LFS. The proband (black square, arrow) presented with medulloblastoma at 9 years of age. NA: not analyzed; wt: wild type; tumor NOS: tumor not otherwise specified. Figure S3 Molecular characterization of medulloblastoma in a pediatric patient with a germline TP53 mutation across diagnosis and recurrences. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: Pediatric Blood & Cancer
Authors: Juan Antonio Ramirez‐Corona, Jose de Jesus Pérez‐Becerra, Víctor Ulises Rodríguez‐Machuca, Uriel Francisco Santana‐Bejarano, Sinhue Alejandro Brukman‐Jimenez, Lucina Bobadilla‐Morales, Mireya Orozco‐Vela, Felipe de Jesús Bustos‐Rodríguez, Regina Navarro Martín Del Campo, Héctor Velázquez‐Santana, Luis Ángel Arredondo‐Navarro, Jorge Román Corona‐Rivera, Alfredo Corona‐Rivera
Institutions: Universidad de Guadalajara, Hospital Civil de Guadalajara
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7125425821