Efficacy of antifibrotic treatment for ANCA-positive fibrosing interstitial lung disease: a retrospective case‒control study
Year: 2026
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Studies verifying the performance of antifibrotic drugs for the treatment of ANCA positive fibrotic ILD (ANCA-fILD) are lacking. MATERIALS AND METHODS: This study assessed the clinical features of ANCA-fILD patients with or without add-on treatment with antifibrotic drugs. A retrospective study involving ANCA-positive patients treated from January 2012 to December 2023 at Peking Union Medical College Hospital was conducted, and a case‒control analysis was performed accordingly. RESULTS: A total of 105 ANCA-fILD patients were identified from 18,617 ANCA-positive patients treated from January 2012 to December 2023 at Peking Union Medical College Hospital; these patients were further divided into an add-on group (31 patients) and a non-add-on group (74 patients). On the basis of baseline FVC%pred matching (± 10%), 30 and 60 patients were ultimately included in the add-on and non-add-on groups, respectively. The decreases in pFVC (p = 0.03), FVC (p = 0.02), DLCO (p = 0.01), and pDLCO (p < 0.01) were less significant in the add-on group than in the non-add-on group. In the related sample analysis, the add-on group did not present significant differences in FVC (p = 0.47), pFVC (p = 0.53), DLCO (p = 0.90), and pDLCO (p = 0.43) between baseline and at the end of the 1-year follow-up, whereas the non-add-on group presented significant decreases in FVC (p < 0.01), pFVC (p < 0.01), DLCO (p < 0.0001) and pDLCO (p < 0.0001). The incidence rates of adverse events and acute exacerbations were similar between the two groups. CONCLUSION: fILD without causing any obvious new-onset adverse reactions.
Source: BMC Pulmonary Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
Award: G8049682881
OpenAlex ID: W7125430875