Work

Data associated with the publication: MPI-guided photothermal therapy of prostate cancer using stem cell delivery of magnetotheranostic nanoflowers

Year: 2025

Type: dataset

Abstract: The datasets within correspond to the Advanced Functional Materials article “MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers.” It centers on using human mesenchymal stem cells (hMSCs) to deliver gold–iron oxide nanoflowers (GIONFs) to prostate tumors and evaluating their intratumoral distribution, retention, and photothermal therapy efficacy. The dataset contains four components: Histology – H&E staining of major organs (liver, kidney, spleen, lung) and tumor sections assessing biosafety, tissue morphology, and treatment response. In vitro data – Characterization of GIONFs, cellular uptake studies, photothermal response measurements, and stem cell labeling assessments. MPI data – Magnetic particle imaging tracking of GIONF-hMSC biodistribution, tumor retention, and whole-body localization over time. PTT data – In vivo photothermal therapy studies evaluating temperature profiles, treatment efficacy, and long-term tumor recurrence following laser irradiation. Together, these data describe the behavior of intracellularly delivered GIONFs, demonstrate the advantages of hMSC-mediated transport for enhanced tumor localization, and support the development of MPI-guided photothermal therapy for prostate cancer.

Source: Research Data Repository, Duke University

DOI: 10.7281/t15av9py