Publisher Correction: Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied
Year: 2026
Type: erratum
Abstract: The original Fig. 1 and the accompanying legend appear below. Fig. 1 Body weight gain trajectories and verification of gene transduction in rats injected with viral vectors expressing GFP or BDNFmyc within the paraventricular nucleus of hypothalamus (PVN). A : Diagram indicating the location of bilateral viral vector injections into the PVN. B : Representative fluorescent images of coronal brain sections ~ 1.8 mm posterior to bregma showing bilateral PVN expression of GFP and unilateral or bilateral PVN expressions of BDNFmyc. 3 V: third ventricle. C : Body weight change of rats involved in immunohistochemical vector verifications. Weight changes from day 0 are expressed as mean ± SEM. Rats with confirmed bilateral PVN expression of BDNFmyc (n = 6) showed a markedly reduced weight gain compared to PVN-GFP controls (n = 6) over the duration of the study. Body weight trajectories from rats with unilateral PVN expression of BDNFmyc (n = 2) are colored in magenta and are not included in the overall PVN-BDNF mean. D : Violin plots show distribution of body weight changes for all PVN-GFP (n = 38) and PVN-BDNF animals (n = 30) included in the study as well as PVN-BDNF rats excluded (n = 10) due to missed injections. The horizontal dotted line shows our body weight change cutoff criteria (127.3 g) used to determine if animals were likely to have bilaterial or unilateral PVN-BDNF injections. Full size image
Source: Scientific Reports
Authors: Jenan Husain, Alexandra Bakhareva, Anna Pace, Maria Noterman-Soulinthavong, Gerald M. Herrera, Benedek Erdos
Institution: University of Vermont
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W7125474666