Work

The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience

Year: 2026

Type: article

Abstract: The 10-year Action for Health in Diabetes (Look AHEAD) clinical trial compared a multidomain intensive lifestyle intervention to a diabetes support and education program with respect to major cardiovascular disease events (primary outcome) and other diabetes- and obesity-related outcomes. Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.

Source: Diabetes Care

DOI: 10.2337/dci25-0126

Authors: Mark A. Espeland, Charles T. Semelka, Stephen B. Kritchevsky, Joni K. Evans, Anne B. Newman

Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Pittsburgh

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases