Work

Discovery of SY-589, a Highly Potent and Orally Bioavailable Polθ Helicase Inhibitor for the Treatment of HR-Deficient Tumors

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02689

Authors: Chongxun Ge, Dazhi Feng, Song Shi, Xuzhen Tang, Yaqi Cui, Song Liu, Yunyue Wang, Shuangtian Tang, Xinnan Li, Xianqiang Sun, Daopeng Yuan, Jinyi Xu, Hu He, Hong Yao

Institutions: China Pharmaceutical University, Tsinghua University

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G4579652716, G6187033865

OpenAlex ID: W7125475965

FWCI: 13.16

Cites: 40

Cited by: 5

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