Oral gabapentin reduces respiratory rate and resistance scores in adult domestic pigeons (Columba livia domestica) during and after handling
Year: 2026
Type: article
Abstract: Objective: To determine whether a single oral dose of gabapentin would generate any changes in heart rate or respiratory rate or behaviors during and after handling of adult domestic pigeons (Columba livia domestica). Methods: Pigeons were housed alone on the day of the study but were otherwise group housed throughout the 9-day study period. Pigeons were assessed before handling and at 1 and 2 hours posttreatment. Behaviors (resting, aggressive, reactionary, maintenance, and feeding behaviors) and physiologic parameters were evaluated before, during, and after handling at each time point. A modified human intruder test, sedation score, and resistance score were developed and compared between time points. Results: As part of a blinded, randomized, crossover study, 20 pigeons received 50 mg/kg of oral gabapentin or an equal volume of tap water (control) with an 8-day washout period. Respiratory rates were significantly higher in the control group at 2 hours during the intruder test and at 1 and 2 hours posttreatment in the period following the exam. Resistance scores were significantly higher in the control group at 2 hours posttreatment during handling. There was no significant difference in heart rates or behaviors. Four pigeons exhibited mild sedation after gabapentin administration. No major adverse effects were observed. Conclusions: Gabapentin administered orally at 50 mg/kg to pigeons decreased respiratory rates and resistance scores during and after examinations for up to 2 hours. Mild sedation was the only adverse effect observed. Clinical Relevance: Oral gabapentin may be beneficial when handling pigeons and may reduce stress associated with handling.
Institution: University of Georgia
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7125477015
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