Risankizumab super responders in moderate-to-severe psoriasis: prevalence, predictors, and long-term maintenance in a multicenter, international, real-world cohort
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background/Objectives The concept of super responders (SRs) has gained increasing attention in psoriasis. However, evidence focusing exclusively on risankizumab remains limited. This multicenter, international, real-world study aimed to assess the prevalence, predictors, and long-term maintenance of SR status among patients with moderate-to-severe plaque psoriasis treated with risankizumab.Methods A retrospective observational study was conducted across 10 Italian and Portuguese referral centers. SRs were defined as patients achieving complete skin clearance (PASI 0) at week 20. Predictors of SR achievement and maintenance were assessed using multivariate logistic regression models at weeks 52, 104, and 130 (2.5 years).Results A total of 1372 patients were included (mean PASI 14.9 ± 8.2). At week 20, 610 (44.5%) achieved PASI 0 and were classified as SRs; 84.4% maintained this status at week 52 and 64.9% at 2.5 years. Biologic-naïve status (OR 1.65; p < 0.001) predicted SR achievement, whereas palmoplantar psoriasis (OR 0.58; p = 0.005) and higher BMI (OR 0.96; p = 0.011) negatively influenced it. Biologic-naïve status remained the strongest predictor of long-term maintenance (OR 2.87; p = 0.003).Conclusions Risankizumab demonstrated high and sustained long-term effectiveness, inducing rapid and sustained complete clearance in a substantial proportion of patients.
Authors: Diego Orsini, Luca Potestio, Matteo Megna, Chiara Assorgi, Antonio Costanzo, Annunziata Dattola, Maria Concetta Fargnoli, Paulo Ferreira, Ana Ferreirinha, Francesca Maria Gaiani, Dario Graceffa, Luciano Ibba, Ana Luísa João, Barbara Leal, Luiz Leite, Maria João Paiva Lopes, Martim Luz, Piergiorgio Malagoli, Pedro Mendes‐Bastos, Francesco Messina, Alessandra Narcisi, Giovanni Pellacani, Rita Pimenta, Ângela Roda, Nello Tommasino, Joana Valério, Tiago Torres
Institutions: Saint Camillus International University of Health and Medical Sciences, San Gallicano Hospital, University of Naples Federico II, Sapienza University of Rome, Humanitas University, IRCCS Humanitas Research Hospital, Hospital CUF Descobertas, Unidade Local de Saúde de São José, Universidade do Porto, Instituto de Ciências Biomédicas Albel Salazar, Hospital Garcia de Orta
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7125488352