Work

The effects of hypoxia inducible factor-1α in myeloid cells and a high-salt diet in a mouse model of orthodontic tooth movement

Year: 2025

Type: article

Abstract: Objective: levels influence OTM under low- and high-salt diets in mice. Methods: expression in myeloid cells received a low-salt (< 0.03% NaCl, tap water) or an high-salt (4% NaCl, saline) diet for two weeks. One week after the start of the diet, an elastic band was inserted between the first and second molars. The expression of inflammatory and bone remodeling genes, bone density, and extent of OTM were determined. Results: deletion increased osteoclast numbers and expression of osteoclast-specific genes. This was paralleled by reduced bone density, which ultimately led to increased OTM. Conclusions: .

Source: The Korean Journal of Orthodontics

DOI: 10.4041/kjod24.295