Age and sex as risk factors for health-related quality of life outcomes in patients with glioma: a CODAGLIO 2.0 analysis
Year: 2026
Type: article
Abstract: BACKGROUND: We assessed the clinical relevance of age and sex as risk factors for health-related quality of life (HRQoL) in patients with adult-type diffuse glioma. MATERIALS AND METHODS: The CODAGLIO 2.0 database contains 16 randomized trials from 5369 patients with glioma. Patients' HRQoL was assessed using EORTC QLQ-C30 and QLQ-BN20 questionnaires. In 8 HRQoL scales, we compared mean HRQoL at baseline with the general population and evaluated factors associated with HRQoL over time using linear mixed models (LMMs). We used the anchor-based minimally important difference to interpret clinically relevant changes. RESULTS: We included 4301 patients with baseline HRQoL followed up to 3 months. Compared to the general population, patients with glioma at baseline had statistically and clinically relevant worse HRQoL, which was still evident after stratifying by age and sex groups. In LMMs, compared to patients aged ≤60 years, those >60 years had statistically significant associations with worse physical functioning: -2.40 (95% confidence interval [CI] -4.14 to -0.71), better social: 4.88 (2.68-7.30) and role: 3.79 (1.39-6.16) functioning, and less fatigue: -3.43 (-5.44 to -1.33) and pain: -4.56 (-6.18 to -2.93). Compared to men, women had statistically significant associations with worse physical and social functioning and more fatigue and pain. Associations between age, sex, and HRQoL were not clinically relevant. Performance status had clinically relevant associations in 5/8 scales. CONCLUSION: Patients with glioma have clinically relevant worse HRQoL compared to the general population. There are statistically but not clinically significant associations between age, sex, and certain HRQoL scales.
Source: The Oncologist
Authors: Ogechukwu A Asogwa, Linda Dirven, Neil K Aaronson, Brigitta G Baumert, Martin van den Bent, Alba A Brandes, Paul M Clement, Corneel Coens, Olivier Chinot, Thierry Gorlia, Ulrich Herrlinger, Caroline Hertler, Florence Keime-Guibert, Emilie Le Rhun, Luigi Lim, Annika Malmström, Christine Marosi, Francesca Martinelli, Matthijs van der Meulen, Kathy Oliver, Andrea Pace, Claudia Panciroli, Jaap C Reijneveld, Mirjam Renovanz, Patrick Roth, Clemens Seidel, Roger Stupp, Wolfgang Wick, Michael Weller, Martin J B Taphoorn, Johan A F Koekkoek, EORTC Quality of Life Group and the EORTC Brain Tumor Group
Institutions: Leiden University Medical Center, The Netherlands Cancer Institute, Kantonsspital Graubünden, Erasmus MC Cancer Institute, Istituto delle Scienze Neurologiche di Bologna, KU Leuven, European Organisation for Research and Treatment of Cancer, European Organisation for Research and Treatment of Cancer, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille, Hôpital de la Timone, University of Bonn, University Hospital Bonn, University of Zurich, University Hospital Zurich, Institut de Recherches Internationales Servier (France), Medical University of Vienna, Istituti di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori Regina Elena, Institut Català d'Oncologia, IRCCS Ospedale San Raffaele, Amsterdam University Medical Centers, Universitätsklinikum Tübingen, Hertie Institute for Clinical Brain Research, University of Tübingen, University Hospital Leipzig, Leipzig University, Northwestern University, Centre Hospitalier Universitaire Vaudois, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, University of Lausanne, German Cancer Research Center, Heidelberg University
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,852
OpenAlex ID: W7125502249