Work

An Optimization Approach for the Production of High-Purity Vitamin C-Nicotinamide Cocrystals by the Gas Antisolvent (GAS) Technique with CO 2 and Ethanol

Year: 2026

Type: article

Abstract: /ethanol could be optimized to overcome the solubility discrepancies between ASC and NIC in ethanol, producing vitamin C cocrystals at higher yields with a marked potential for nutritional and pharmaceutical applications.

Source: ACS Omega

DOI: 10.1021/acsomega.5c08253

Authors: Clóvis A. Balbinot Filho, Thayli R. Araujo, Jônatas L. Dias, Evertan A. Rebelatto, Adailton J. Bortoluzzi, Mariana M. Vernaschi, Tânia B. Creczynski-Pasa, Sandra R. S. Ferreira, Marcelo Lanza

Institution: Universidade Federal de Santa Catarina

Language: English

Topic: Crystallization and Solubility Studies

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico

Awards: G1033608794, G3324649130, G3409413252, G7194538209

OpenAlex ID: W7125503789

FWCI:

Cites: 61

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