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Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp2)-H Bond Selenylation/Annulation of Enaminones

Year: 2026

Type: article

Abstract: Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp2)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.

Source: Molecules

DOI: 10.3390/molecules31020391

Authors: João M. Brito, Isabella M. e Oliveira, Cassio A. O. Moraes, Alex R. Schneider, Tiago E. A. Frizon, Giancarlo V. Botteselle, Vijay P. Singh, André L. Stein, Gleison A. Casagrande, Giuseppe A. Camara, Antonio L. Braga, Jamal Rafique, Sumbal Saba

Institutions: Universidade Federal de Goiás, Universidade Federal de Mato Grosso do Sul, Universidade Federal de Santa Catarina, Universidade Estadual do Centro-Oeste, Panjab University, Universidade Federal de Mato Grosso

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade Federal de Goiás, Universidade Federal de Mato Grosso do Sul

OpenAlex ID: W7125509901

FWCI:

Cites: 94

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