Year: 2026
Type: article
Abstract: Type 2 diabetes (T2D) risk prediction remains a challenge, particularly in underrepresented populations, including people living with HIV (PWH) and those of non-European ancestry. We evaluated the performance of two metaPRS (polygenic risk score) models, integrating genetic markers related to inflammation and lipid metabolism, in predicting T2D risk across ancestry groups (African and European), with and without HIV. The metaPRS were generated in a subset from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study (6,034 Black; 11,972 White) and validated in 7,580 (4,120 Black; 3,460 White) PWH from the Centers for AIDS Research of Integrated Clinical Systems (CNICS), as well as an additional 4,152 (2,586 Black; 1,566 White) seronegative participants from REGARDS. Incorporating the metaPRS into models provided non-significant improvements in T2D risk prediction compared to single-trait T2D PRS and clinical risk factors. Performance was similar in PWH and in people without HIV, suggesting that these general population-derived genetic scores are transferable to PWH. Future studies should focus on refining PRS models in diverse populations and exploring genetic factors specific to PWH regarding T2D risk.
Source: Scientific Reports
Authors: Nicole D. Armstrong, Vinodh Srinivasasainagendra, Lavanya Pilla, Radhika Gangaraju, Peter W. Hunt, Robin M. Nance, Heidi M. Crane, Inga Peter, Sonya L. Heath, Greer A. Burkholder, Richard D. Moore, Jeffrey M. Jacobson, Edward R. Cachay, Thibaut Davy-Mendez, Hirotaka Iwaki, Lana Sargent, Hemant K. Tiwari, Marguerite R. Irvin
Institutions: University of Alabama at Birmingham, University of California, San Francisco, University of Washington, Icahn School of Medicine at Mount Sinai, Johns Hopkins University, Case Western Reserve University, Mayo Clinic in Arizona, University of North Carolina at Chapel Hill, National Institutes of Health, National Institute on Aging, Virginia Commonwealth University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: U.S. Department of Health and Human Services, Vanderbilt University, University of Miami, University of Washington, Johns Hopkins University, Case Western Reserve University, National Institutes of Health, Center for AIDS Research, University of Washington, University of California, San Diego, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke
Awards: G1203476693, G1255407591, VCID and Stroke in a Bi-racial National Cohort, G1459159051, G1531094742, G1671748052, G1722716446, G1939027404, G1940277482, G2122320390, G2140171847, G2213881162, G2219438539, G2230551448, G2258234602, G2483435703, G2525095458, G2784128823, G2839755957, G2898952431, G2970457639, G3040019378, G3138949240, UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and Research, G342295615, G378552126, G3789320706, G3917235369, G3985073149, G4038955393, G4166928756, G4235606768, G4391827178, G4575219416, G4610217253, G4847806209, G495691247, G5431849782, Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV, G5783814435, G5886955022, G5934524914, G6061530938, G6333266910, G6345323600, G6471454067, G6488665543, G654751394, G6625095162, Immunologic and Fat-Associated Predictors of Insulin Resistance in Treated HIV, G7178514535, G719869049, G7364671334, G744069829, G7791962275, G8259150102, G8379618618, G8541996175, Genome wide SNP analysis in Parkinson's disease, G9000001180, G9000008877, G9000016284, G9000036922, G9000054876, G9000058579, G9000074434, G9000075494, Tennessee Center for AIDS Research (TN-CFAR), G9000078127, G9000081321, G9000100957, G9000121584, G9000124410, G9000129761, G9000186273, G9000186388, G9000189727, G9000191827, G9000274539, G9000299978, G9000313355, G9000343736, Addressing Barriers to the Comprehensive Use of Statins in HIV: The ABACUS-HIV Study, Impact of Asymptomatic CMV on Cardiovascular Event Risk in Treated HIV, San Diego Center for AIDS Research (SD CFAR), Shared and novel contributors to risk of stroke and stroke recurrence in a multiethnic population – the role of social determinants of health, genetics, and epigenetics, Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR), The Johns Hopkins Center for AIDS Research (JHU CFAR), Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV, UAB Center for AIDS Research (CFAR), G90079629, G906911976, G929137571, G939786002, G940002362, G94475886, G97119092
OpenAlex ID: W7125527602