Work

Mechanochemical Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)

Year: 2026

Type: article

Abstract: Over the last 15 years, significant progress has been made in developing mechanochemical approaches for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, utilizing various starting materials and different copper sources and process parameters. This synopsis systematically discusses developments in the mechanochemical CuAAC reaction, aiming not only to highlight the benefits of employing this approach for designing molecules featuring a 1,2,3-triazole motif but also to provide a comprehensive guide for chemists interested in exploring this area and to stimulate future advances in the field.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02481

Author: Artur Kasprzak

Institution: Warsaw University of Technology

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: Politechnika Warszawska