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Abstract Tu0068: The Microanatomy of the Human Hemodialysis Fistula Maturation and Failure

Year: 2026

Type: conference-abstract

Abstract: Clinical maturation of arteriovenous fistulas (AVF) is largely determined by the adaptive response of the vein to extreme hemodynamic conditions. Histological and bulk transcriptomic analyses of human veins indicate that this is a profound mechanosensitive and inflammatory reparative process, with subtle molecular differences separating maturation and failure. To look for these subtle changes, we analyzed the microanatomy of veins and AVFs that matured and failed using single-cell RNA sequencing (70,281 cells from 20 individuals) and immunofluorescence (IF, n=48 cross-sections).

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2025.100352

Authors: Laisel Martinez, Filipe Stoyell, Marwan Tabbara, Miguel Rojas, Simone Pereira-Simon, Nieves Santos Falcon, Xiaofeng Yang, YAN-TING SHIU, Timmy Lee, Juan Duque, Loay Salman, Xiaochun Long, Roberto Vazquez-Padron

Institutions: University of Miami, Temple University, University of Utah, University of Alabama at Birmingham, Albany Medical Center Hospital, Augusta University

Language: English

Topic: Central Venous Catheters and Hemodialysis

Subfield: Emergency Medical Services

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

OpenAlex ID: W7125578254

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