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Abstract We0061: Somatostatin-Based Near-infrared Fluorescence Probe for Imaging Macrophage Inflammation in Atherosclerosis

Year: 2026

Type: conference-abstract

Abstract: Atherosclerotic plaque inflammation, driven by activated macrophages, is a major contributor to plaque rupture and acute coronary syndromes. Somatostatin receptor subtype 2 (SSTR2), expressed on activated macrophages, represents an ideal target for molecular imaging, and has been imaged in larger arteries using clinical PET imaging. This study evaluates the potential of a novel near-infrared fluorescence (NIRF) somatostatin-based probe to image macrophage-driven plaque inflammation, with new potential applicability to human coronary sized arteries.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2025.100374

Authors: Mohamad Kassab, Khanh Ha, Yoichiro Kawamura, Guillermo Tearney, Alessandro Maino, Jason McCarthy, Farouc Jaffer

Institutions: Harvard University, Masonic Medical Research Laboratory, National Cerebral and Cardiovascular Center, Massachusetts General Hospital

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

OpenAlex ID: W7125579077

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