Abstract Tu0081: In a murine model of PAD, genetic loss of the absent in melanoma 2 (AIM2) inflammasome promotes regional transcriptional activity favoring regeneration, cellular communication and management of oxidative stress
Year: 2026
Type: conference-abstract
Abstract: We previously showed that the absent-in-melanoma 2 (AIM2) inflammasome is expressed in PAD myoblasts, reduces their ability to differentiate, and may cause myopathy. Here, using spatially resolved genetic profiling, we tested the hypothesis that beneficial effects of AIM2 inhibition in myoblasts can be detected in vivo, associated with genetic features favoring regeneration, and linked to greater cell-cell communication in muscle ischemia.
Source: JVS Vascular Science
Authors: Ulka Sachdev, Paul Cantalupo, Bowen Xie, Edwyn Assaf, Rohan Kulkarni, Ryan McEnaney, Uma R Chandran
Institution: University of Pittsburgh Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W7125581054
Cites:
Cited by:
Related to: