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Abstract Th0043: In vivo CRISPR-Screening Identifies Fhl3 as a Potential Regulator of Macrophage Accumulation in Atherosclerotic Plaques

Year: 2026

Type: conference-abstract

Abstract: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and disability worldwide. Recent clinical trials have shown that inflammation plays a critical role in ASCVD. Plaque inflammation is primarily driven by inflammatory macrophage accumulation and is associated with unstable lesions and poor patient outcomes. scRNA-Sequencing studies have highlighted diverse macrophage populations in atheromas, but fundamental questions persist about how macrophages acquire these transcriptional states and influence pathogenesis.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2025.100311

Authors: Huajun Liao, Cesar De Jeronimo Diaz, Dina Levy-Lambert, Adam Oskowitz, Trevor Fidler

Institution: University of California, San Francisco

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

OpenAlex ID: W7125586858

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