Abstract Tu0049: Leveraging a Transgenic Mouse Model to Study Endothelial Cell-Derived Extracellular Vesicles in Atherosclerosis
Year: 2026
Type: conference-abstract
Abstract: Atherosclerosis is characterized by the accumulation of lipoproteins and immune cells, leading to unresolved inflammation in the arterial wall. Endothelial cells (EC) form a barrier, and modulate communication, between circulating and resident vascular cells. EC dysfunction, a hallmark of the disease, disrupts healthy communication. Extracellular vesicles (EVs) are key mediators of intercellular communication, carrying bioactive molecules that influence cell function and signal disease states. While our group previously demonstrated crosstalk between endothelial-derived EVs (EC-EVs) with monocytes and smooth muscle cells in vitro, their role in vivo remains unclear.
Source: JVS Vascular Science
Institutions: University Health Network, University of Virginia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W7125589692