Abstract We0084: Hypoxia mediates JMJD3-dependent angiogenesis in wound microvascular endothelial functions
Year: 2026
Type: conference-abstract
Abstract: Proper wound repair requires restoration of the microcirculation. A process mediated primarily by endothelial cells (ECs) activated by the hypoxic wound environment. Under normal wound healing conditions, the activation of ECs elicits the transition from a quiescent to an active state, characterized by heightened migration and proliferation of ECs. Here, the control of EC phenotype transitioning is unclear; however, recent literature has suggested that epigenetic regulation may occur. We identified that a histone demethylase, JMJD3, regulates active genes in murine dermal microvascular ECs and may be critical for the EC transition from a quiescent to an active state.
Source: JVS Vascular Science
Institution: University of Michigan
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W7125591601
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