Work

Abstract Tu0025: Single cell and spatial multi-Omics show the Regulation and Therapeutic Potential of Venous Smooth Muscle Cell Reprogramming during Arteriovenous Fistula Remodeling

Year: 2026

Type: conference-abstract

Abstract: The autogenous arteriovenous fistula (AVF) remains the preferred vascular access for hemodialysis, despite its high rate of maturation failure, primarily due to occlusive stenosis driven by fibrotic remodeling and neointimal hyperplasia. Currently, no therapies effectively improve AVF outcomes, largely due to limited understanding of the cellular and molecular mechanisms underlying venous remodeling. To address this knowledge gap, we conducted single-nucleus (sn) RNA/ATAC-seq analysis using a translational aortocaval fistula model in mice.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2025.100341

Authors: shuilin dong, Chunhui Wang, Carly Thaxton, Austin Lowery, Lily Liu, xiaoliang wu, William Bryant, xWeix xZhangx, Laisel Martinez, Kunzhe Dong, Yanfang Zhu, Wantien Chiang, Harold Singer, Alan Dardik, Roberto Vazquez-Padron, Xiaochun Long

Institutions: Augusta University, Yale New Haven Hospital, Temple University, University of Miami, Albany Medical College, Yale University

Language: English

Topic: Central Venous Catheters and Hemodialysis

Subfield: Emergency Medical Services

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

OpenAlex ID: W7125592976

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